I have spent way too much time on reading comic strips. Here are some I read regularly:

Sinfest – Irreverent comedy.

UserFriendly – Proper geek humor (No longer updated)

Homestar Runner – Not a comic, but close enough.

 Non-Sequitur – Nuff said.

Foxtrot

Garfield

Wapsi Square – Weird.

El Goonish Shive – Weirder.

Girl Genius – Jules Verne would be proud.